Effects of Aflatoxin on the Performance of Broiler Breeders and Its Alleviation through Herbal Mycotoxin Binder

Authors
1 Department of Animal Science, Faculty of Agricultural Sciences, Malayer University, Malayer, Islamic Republic of Iran.
2 Department of Animal Science, Faculty of Agricultural Sciences, Lorestan University, Khoramabad, Islamic Republic of Iran.
Abstract
This study was conducted to investigate the effect of Aflatoxin B1 (AFB1) on performance and egg quality in broiler breeders and the abatement of its deteriorative effect through its counteraction with Herbal Mycotoxin Binder (HMB). Thirty-six, 28-wk-old broiler breeder hens were allotted to one of the three treatments of: (1) basal diet (control),(2) control plus 500 μg kg-1 AFB1 and (3) control diet plus 500 μg kg-1 AFB1+0.2%HMB for three periods, each of a duration of three weeks and when from 28 to 36 weeks of age. Results revealed that 500 μg kg-1 AFB1 significantly (P< 0.05) reduced feed consumption, feed efficiency, egg production as well as egg weight. Supplementation of HMB partially restored feed consumption and egg production alleviating some side effects of AFB1.

Keywords


1. AOAC International 1995. Official Methods of Analysis of AOAC International. 16th Edition, Association of Official Analytical Chemists, Washington, DC.
2. Amani, A. R., Somchit, M. N., Konting, M. M. B. and Kok, L. Y. 2010. Vitamin E and Curcumin Intervention on Lipid-peroxidation and Aِntioxidant Defense System. J. Amer. Sci., 6(3): 52-62.
3. Chowdhury, S. R. and Smith, T. K. 2004. Effects of Feeding Blends of Grains Naturally Contaminated with Fusarium Mycotoxins on Performance and Metabolism of Laying Hens. Poult. Sci., 83: 1849–1856.
4. Denli, M. J., Blandon, C., Guynot, M. E., Salado, S. and Perrez, J. F. 2008. Efficacy of a New Ochratoxin-binding Agent (OcraTox) to Counteract the Deleterious Effects of Ochratoxin A in Laying Hens. Poult. Sci., 87: 2266-2272.
5. Duncan, D. B. 1955. Multiple Range and Multiple F Tests. Biometrics, 11: 1-42.
6. Fanelli C, Fabbri, A. A., Picretti, S., Finotti, S. and Passi, S. 1985. Effect of Different Antioxidants and Free Radical Scavengers on Aflatoxin Production. Mycol. Res., 85: 65-69.
7. Fernandez A., Verde, M. T., Gascon, M., Ramos, J., Gomez, J., Luco, D. F. and Chavez, G. 1994. Variations of Clinical Biochemical Parameters of Laying Hens and Broiler Chickens Fed Aflatoxin Containing Feed. Avian Pathol., 23: 37-47.
8. Galvano F., Piva, A., Ritieni, A. and Galvani, G. 2001. Dietary Strategies to Counteract the Effects of Mycotoxins: A Review. J. Food Protect., 64: 120–131.
9. Garlich J. D., Tung, H. T. and Hamilton, O. B. 1973. The Effects of Short Term Feeding of Aflatoxin on Egg Production and Some Plasma Constituents of the Laying Hen. Poult. Sci., 52: 2206-2211.
10. Gill, J. L. 1985. Design and Analysis of Experiments in the Animal and Medical Science. Iowa State University Press, USA, PP 399.
11. Gowda, N. K. S., Ledoux, D. R., Rottinghaus, G. E., Bermudez, A. J. and Chenty, Y. C. 2008. Efficacy of Turmeric (Curcuma longa), Containing a Known Level of Curcumin, and Hydrated Sodium Calcium Aluminosilicates to Ameliorate the Adverse Effects of Aflatoxin in Broiler Chicks. Poult. Sci., 87: 1125-1130.
12. Gowda N. K. S. and Ledoux, D. R. 2008. Use of Antioxidants in Amelioration of Mycotoxin Toxicity: A Review. Anim. Nutr. Feed Techn., 8: 1-11.
13. Hamilton, P. B. and Garlich, J. D. 1971. Aflatoxin as a Possible Cause of Fatty Liver Syndrome in Laying Hens. Poult. Sci., 50: 800-804.
14. Huff, W. E., Wyatt, R. D. and Hamilton, P. B. 1975. Effects of Dietary Aflatoxin on Certain Egg Yolk Parameters. Poult. Sci., 54: 2014-2018.
15. Huff, W. E., Kubena, L. F., Harvey, R. B. and Phillips, T. D. 1992. Efficacy of Hydrated Sodium Calcium Aluminosilicate to Reduce the Individual and Combined Toxicity of Aflatoxin and Ochratoxin A. Poult. Sci., 71: 64-69.
16. Yu, I., Goryacheva, S., De, S., Barbara, D., Marieke, L., Sergei, A. E., Ildiko, B. and Carlos Van, P. 2007. Simultaneous Non-instrumental Detection of Aflatoxin B1 and Ochratoxin A Using a Clean-up Tandem Immunoassay Column. Analytica Chimica Acta, 590: 118-124.
17. Iqbal, Q. K., Rao, P. V. and Reddy, S. J. 1983. Dose-response Relationship of Experimentally Induced Aflatoxicosis in Commercial Layers. Ind. J. Anim. Sci., 53: 1277-1280.
18. Jay, E. M., Peter, J. C. and Michael, K. D. 2007. Aspergillus flavus Hydrolases: Their Roles in Pathogenesis and Substrate Utilization. Appl. Microbiol. Biotechnol., 77: 497–504
19. Jewers, K. 1990. Mycotoxins and Their Effect on Poultry Production. Options Méditerranéennes, 7(A): 195-202.
20. Johri, T. S., Agrawal, R. and Sadagopan, V. R. 1990. Effects of Low Dietary Levels of Aflatoxin on Laying Quails (Coturnix coturnix Japonica) and Their Response to Dietary Modifications. Ind. J. Anim. Sci., 60: 355-359.
21. Kim, J. G., Lee, L. W., Kim, P. G., Roh, W. S. and Shintani, H. 2003. Reduction of Aflatoxins by Korean Soybean Paste and Its Effect on Cytotoxicity and Reproductive Toxicity. Part 3. Inhibitory Effects of Korean Soybean Paste (Doenjang) on Aflatoxin Toxicity in Laying Hens and Aflatoxin Accumulation in Their Eggs. J. Food Protec., 66: 866-873.
22. Lee, S. E., Campbell, B. C., Russel, J., Hasegawa, S., Molyneux, R. J., and Lee, H. S. 2001. Inhibitory Effects of Naturally Occurring Compounds on Aflatoxin B1 Biotransformation. J. Agr. Food Chem., 49: 5171-5177.
23. McDaniel, G., Ronald, D. A. and Coleman, M. A. 1979. The Effect of Egg Shell Quality on Hatchability and Embryonic Mortality. Poult. Sci., 58: 10-13.
24. Manafi, M., Umakantha, B., Narayanaswamy, H. D. and Mohan, K. 2009a. Evaluation of High Grade Sodium Bentonite on Performance and Immune Status of Broilers, Fed with Ochratoxin and Aflatoxin. World Myco. J., 2(4): 435-440.
25. Manafi M., Narayanaswamy, H. D. and Pirany, N. 2009b. In vitro Binding Ability of Mycotoxin Binder in Commercial Broiler Feed. Afr. J. Agr. Res., 4(2): 141-143.
26. Manafi, M., Umakantha, B. and Narayanaswamy, H. D. 2009c. In vitro Evaluation of Clay Material for its Binding Ability to Adsorb Mycotoxins in Broiler Chicken Diet. Ind. Vet. J., 86: 1246-1249.
27. Manafi, M., Mohan, K. and Noor Ali, M. 2011. Effect of Ochratoxin A on Coccidiosis-Challenged Broiler Chicks. World Myco. J., 4(2): 177-181.
28. Muthiah, J., Reddy, P. R. and Chandran, N. D. J. 1998. Effect of Graded Levels of Aflatoxin B1 and the Effect of Direct Fed Microbial (DFM) on Egg Production in Egg Type Breeders. Ind. Vet. J., 75: 234-233.
29. North, M. O. 1990. Commercial Chicken Production Manual. Fourth Edition, Chapmon and Hall, New York, PP. 913.
30. Pandey, I. and Chauhan, S. S. 2007. Studies on Production Performance and Toxin Residues in Tissues and Eggs of Layer Chickens Fed on Diets with Various Concentrations of Aflatoxin B1. British Poult. Sci., 48: 713-723.
31. Phillips, T. D., Kubena, L. F., Harvey, R. B., Taylor, D. R. and Heidelbaugh, N. D. 1988. Hydrated Sodium Calcium Aluminosilicate: A High Affinity Sorbent for Aflatoxin. Poult. Sci., 67: 243-247.
32. Raju, M. V. L. N. and Devegowda, G. 2002. Sterified Glucomannan in Broiler Chicken Diets Contaminated with Aflatoxin, Ochratoxin and T-2 Toxin: Evaluation of Its Binding Ability (In vitro) and Efficacy as Immunomodulator. Asian-Aust. J. Anim. Sci., 15: 1051-1055.
33. Roche Company. 1969. Roche Company Yolk Color Fan No. 1155. Printed in Switzerland.
34. Rukmini, C. and Bhat, R. V. 1978. Occurrence of T-2 Toxin in Fusarium Infested Sorghum from India. J. Agr. Food Chem., 26: 647-649.
35. SAS User’s Guide. 2004. Version 9.2 ed. SAS Inst. Inc., Cary, NC.
36. Srinivas, L., Shalini, V. K. and Shylaja, M. 1992. Turmerin: A Water Soluble Antioxidant Peptide from Turmeric (Curcuma longa). Arch. Biochem. Biophys., 292(2): 619-623.
37. Sims, W. M., Kellys, J. R. D. C. and Sanford, P. E. 1970. A Study of Aflatoxicosis in Laying Hens. Poult. Sci., 49: 1082-1084.
38. Soni, K. B., Rajan, A., and Kuttan, R. 1992. Reversal of Aflatoxin Induced Liver Damage by Turmeric and Curcumin. Cancer Letters, 66: 115-121.
39. Soni, K. B., Lahiri, M., Chackradeo, P., Bhide, S. V. and Kuttan, R. 1997. Protective Effect of Food Additives on Aflatoxin-induced Mutagenicity and Hepatocarcinogenicity. Cancer Letters, 115(2): 129-33.
40. Smith, J. E. and Hamilton, P. B. 1970. Aflatoxicosis in the Broiler Chicken. Poult. Sci., 49: 207-215.
41. Stephen, R., Pesti, G. M. and Wyatt, D. 1991. Effect of Tryptophan Supplementation and Aflatoxicosis in Laying Hens. Poult. Sci., 70: 307-312.
42. Surai, P. F. 2001. Natural Antioxidants in Avian Nutrition and Reproduction. 1st Edition, Nottingham University Press, UK, PP. 81-91.
43. Sweeney, M. J. and Dobson, A. D. 1998. Mycotoxin Production by Aspergillus, Fusarium and Penicillium Species. Int. J. Food Microbiol., 43(3): 141-158.
44. Thapa, N. K. 2008. Pathological Effects of Aflatoxicosis in Layer Chicken with Special Emphasis on Reproductive Pathology. MVSc. Thesis, Tamil Nadu Veterinary and Animal Sciences University.
45. Verma, J, Johri, T. S., Swan, B. K. and Ameena, S. 2004. Effect of Graded Levels of Aflatoxin and Their Combination on the Performance and Immune Response of Broilers. British Poult. Sci., 45: 512-518.
46. Vieira, S. L. 2003. Nutritional Implication of Mould Development in Feed Stuffs and Alternatives to Reduce the Mycotoxin Problem in Poultry Feeds. World Poultr. Sci. J., 59: 111-112.
47. Washburn, K. W., Wyatt, R. D., Potts, P. L. and Lanze, G. M. 1985. Effects and Mechanism of Aflatoxin Variation in Shell Strength. Poult. Sci., 64: 1302-1305.
48. Yegani, M., Smith, T. K., Leeson, S. and Boermans, H. J. 2006. Effects of Feeding Grains Naturally Contaminated with Fusarium Mycotoxins on Performance and Metabolism of Broiler Breeders. Poult. Sci., 85: 1541-1549.
49. Zaghini, A., Martelli, G., Ronchada, P. and Rizzi, L. 2005. Mannanoligosaccharides and Aflatoxin B1 and M1 Residues in Fed of Laying Hens. Effect on Egg Quality, Aflatoxin B1 and M1 Residue in Eggs and Aflatoxin B1 Levels in Liver. Poult. Sci., 84: 825-832.